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Chiral pool synthesis is a strategy that aims to improve the efficiency of chiral synthesis. It starts the organic synthesis of a complex enantiopure chemical compound from a stock of readily available enantiopure substances. Common chiral starting materials include monosaccharides and amino acids. The built-in chirality is then preserved in the remainder of the reaction sequence. This strategy is especially helpful if the desired molecule bears a great resemblance to cheap enantiopure natural products. Otherwise, a long, tortuous synthesis involving many steps with attendant losses in yield may be required. At times, it may be difficult to find a suitable enantiopure starting material; other techniques may prove more fruitful. General methods used in chiral pool synthesis are the use of protecting groups, and functional group interconversion (FGI). ==Examples== Chiral pool synthesis is used to build a part of the epothilone molecule (an alternative to Paclitaxel), from readily available enantiopure (–)-pantolactone. Enantiopure tartaric acid is also used to synthesize chiraphos: : 抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)』 ■ウィキペディアで「Chiral pool synthesis」の詳細全文を読む スポンサード リンク
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