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・ Chiral anomaly
・ Chiral auxiliary
・ Chiral color
・ Chiral column chromatography
・ Chiral derivatizing agent
・ Chiral gauge theory
・ Chiral homology
・ Chiral knot
・ Chiral Lewis acid
・ Chiral Lie algebra
・ Chiral ligand
・ Chiral model
・ Chiral perturbation theory
・ Chiral Photonics
・ Chiral polytope
Chiral pool synthesis
・ Chiral Potts curve
・ Chiral Potts model
・ Chiral resolution
・ Chiral superfield
・ Chiral symmetry breaking
・ Chirala
・ Chirala (Assembly constituency)
・ Chirala mandal
・ Chirala railway station
・ Chirala, Kashmir
・ Chiraleș River
・ Chirality
・ Chirality (chemistry)
・ Chirality (disambiguation)


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Chiral pool synthesis : ウィキペディア英語版
Chiral pool synthesis
Chiral pool synthesis is a strategy that aims to improve the efficiency of chiral synthesis. It starts the organic synthesis of a complex enantiopure chemical compound from a stock of readily available enantiopure substances. Common chiral starting materials include monosaccharides and amino acids. The built-in chirality is then preserved in the remainder of the reaction sequence.
This strategy is especially helpful if the desired molecule bears a great resemblance to cheap enantiopure natural products. Otherwise, a long, tortuous synthesis involving many steps with attendant losses in yield may be required. At times, it may be difficult to find a suitable enantiopure starting material; other techniques may prove more fruitful.
General methods used in chiral pool synthesis are the use of protecting groups, and functional group interconversion (FGI).
==Examples==
Chiral pool synthesis is used to build a part of the epothilone molecule (an alternative to Paclitaxel), from readily available enantiopure (–)-pantolactone. Enantiopure tartaric acid is also used to synthesize chiraphos:
:

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